As you may know, when you request a CFM file that doesn't exist, you don't get the normal 404 error page that you may have setup in your web server, instead you get a CF error. This is simple enough to solve in IIS, you simply tell the server to ensure scripts exist in regards to cfm processing.
However - how is this done for Apache?
Edited: I know about the missing handler setting in the CF admin, however, this is for a box with N virtual servers on it and I'd want a different 404 handler for each server.