The game has you hopping between dimensions hunting down pieces of some kind of magic rock. Along the way you encounter many of Spider-Man's classic villains. Now - growing up - I was a Spider-Man fan. I didn't buy many of the comics, but I'd pick up an issue from time to time. I was also a big fan of the corny cartoon growing up. Even with my probably mediocre understanding of Spider-Man's villains I find the game has an incredible line up. Even better - many of the baddies are presented in alternate versions which makes things even more interesting. Enemies like the Vulture, Hobgoblin, and the Sandman are presented very cool.
Game play wise everything works well - but swinging - at times - can be a bit confusing. I was concerned that it would be the weakest point of the game - and it probably is. But it isn't nearly as bad as I thought it would be. Once you get used to the basic concepts of traveling by web you get the hang of it. There are a few points in the game where control is frustrating but for the most part - it just works. My youngest son is playing the game currently and he's farther along than I am so I think just about anyone can pick up the game and play well.
Graphics are well done - see the screen shots below. I've commented already that I really like the design of the bosses, but the levels are also great. Audio wise there isn't much to comment on. There is no background music that I'm aware of. I can say though that the Spider-Man "chatter" is dead on perfect. Multiple times both myself and my kids laughed out loud based on some smart ass remark Spidey made. I can also say that the Deadpool level is very funny. (There is - I kid you not - a conversation about henchmen uniforms that will have you cracking up.)
Any way - this is one of those games where I did not expect to enjoy it nearly as much as I am. I definitely recommend picking it up - especially if you like the comics. (As a side question - what's the best Spider-Man comic for a person to start picking up again?)